The Effect of Neural Entropy during Deep Brain Stimulation of Cortex-Basal Ganglia Network Model.

Abstract

Researchers reported decreased nerve entropy Patients with Parkinson's disease (PD) have abnormalities in their basal ganglia (BG). Studies of local field potentials (LFPs) recorded from the hypothalamus and single unit recordings of GP neurons showed this reduction to be significant. According to this hypothesis, these changes are consistent with changes in the ability of the basal ganglion network to encode PD information. Our deep brain stimulation of cortical basal ganglia (DBS) model includes single LFP recordings and shows how entropy changes during DBS. In addition to the extracellular stimulation of supplied STN fibers and LFP mimetics, which are detected differently on a registered electrode, this model includes osteoclast activation and anti-apoptosis. In the DBS network, the firing pattern fluctuated between high-frequency and low-frequency stimuli, since gp neurons in the network showed a decrease in entropy when a high-frequency stimulus was applied and an increase in entropy when a low-frequency stimulus was applied. Second hand. Changes in neural entropy after DBS have been reported experimentally. The simulation results were consistent