Tansdermal Gel Formulation Designing & Evaluation: A Novel Apporach for Drug Delovery through Skin

Abstract

The lipophilic nature of majority of newly developed drugs has resulting in poor bioavailability, and pharmacokinetic variations. The goal of this evaluation is to evaluate and report the current potential and future scope of gel formulation for becoming an effective delivery system for poorly water-soluble drugs. Gel consist two different systems in which drug containing nanoemulsionis incorporated into a gel base.Topical gel are transparent or translucent semisolid formulation and used for the localized drug delivery anywhere in the body through rectal, vaginal, ophthalmic and skin as topical route. Gel formulation provides better application property and stability in comparision of ointment and cream. Gel has emerged as one of the most interesting topical delivery system as it has dual release control system i.e. Hydrogel and nanoemulsion. Gel having rapidly penetrates and deliver active substance deeper and quicker. The use of gels can be considered well in analgesics and antifungal drugs. In recent year there has been great interest in the use of novel polymer with complex function such as emulsifiers and thickeners. The gelling capacity of this compound allows the formulation of stable emulsion and creams by decreasing surface and interfacial tension at the same time increasing the viscosity of aqueous phase. In spite of many advantage of gels a major limitation is in the delivery of hydrophobic drug. So to overcome this limitation an emulsion based approach is being used to that even a hydrophobic moiety can enjoy the unique property of gel.