Design, Development and Evaluation of Immediate Release Tablet of Glimepride Using SSG and Crosscarmellose Sodium

  • Arghyadeep Saha, Amandeep Singh, Mohit Kumar, Balvinder Khatri

Abstract

The oral route is the most common way of administering drugs, and among the oral dosage forms tablets of various different types are the most common.Tablets may be defined as unit forms of solid medicament prepared by compaction.  Immediate release tablet are those tablet which disintegrate and release the drug rapidly once it enters the GIT.  Recently immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because they are easy to administer and lead to a better patient compliance.

The present work involves formulation development and in-vitro evaluation of glimepiride immediate release tablet by wet granulation method. Tablet was prepared using sodium starch glycolate, lactose monohydrate, crosscarmellose sodium, corn starch, and magnesium serrate. The superdisintegrant sodium starch glycolatewas used in the 3%, 4%, and 5% concentration in formulation F1, F2, and F3 respectively. During the course of study it was found that the increasing concentration of superdisintegrant had more effect in dissolution and in-vitro release. Formulation F3 in which superdisintegrant sodium starch glycolate was used in 5% concentration gave better result than the other formulations. Stability evaluations also confirmed that F3 was the best formulation. Thus F3 fulfills all the criteria for an optimized formulation.

Published
2021-11-19
How to Cite
Arghyadeep Saha, Amandeep Singh, Mohit Kumar, Balvinder Khatri. (2021). Design, Development and Evaluation of Immediate Release Tablet of Glimepride Using SSG and Crosscarmellose Sodium. Design Engineering, 13780 - 13793. https://doi.org/10.17762/de.vi.6496
Section
Articles